Linux can’t prevent you from permanently removing files. While in Windows it’s a chore to remove a number of files/bloat, which are then most often back after a system update.
“I would rather have questions that can’t be answered than answers that can’t be questioned.” - Rich Feynman
Linux can’t prevent you from permanently removing files. While in Windows it’s a chore to remove a number of files/bloat, which are then most often back after a system update.
In Fedora? I’ve had one or two issues with the updater if I postponed the updates for a while, yet sudo dnf update always fixed the issue. I feel like thats step one for terminal use really. It’s also nice when it’s done this way you typically don’t need to reboot, unless it’s kernel or driver updates.
I feel like Mint is the move if you never want to utilize the terminal. But while it can be intimidating initially, after using it, you’ll grow to love it. Truly makes life way easier. I learned by first finding threads on my issues to copy and paste commands. After doing that enough you’ll gain an understanding of the main commands pretty quick. Fedora is a great starter in my mind, as you can do everything through the GUI when first starting, but unlike Mint, you can still get nerdy with the terminal when you feel up to it. Using a VM is a solid option to learn the terminal without any risk, worst case just delete the VM and make another. But you’d have to mess up pretty thoroughly to need to do that in my experience. Fedora, or Nobara which is a gaming and media centric fork of Fedora, are amazing due to the ability to run great out of the box plus being able to dial in anything you want to alter for your needs down the road. Fedora’s Software center allows you to add flatpak and snap packages, so it’ll all be in one place. Fedora 40 makes NVIDIA drivers pretty easy to deal with too. But this is just my two cents, I’m curious to see what others recommend for you.
Good on you for being so knowledgeable about the disorder. But 100% ask your doc, being real with my doc has taken our appointments to the next level. The genome is only half of the IgE allergy response, other half is the environment you were raised in as you can build tolerance of it. A high genetic aspect can be countered by a “low hygienic” environment according to research.
Well, in digging into some research papers, I found “mast cell activation can be caused by both IgE-mediated and non–IgE-mediated triggers”.
This is because there can be a mast cell mutation (KIT) which then doesn’t require IgE for activation. You have MMAS and not Mastocytosis, right? The mutation seems to be associated with Mastocytosis based on my understanding from the paper.
Since mast cells aren’t privileged, they’re restricted from entering sites like the brain and spinal cord. So, if they’re in the spinal cord, you almost certainly have bigger problems than mast cell activation I’d think, as the barrier isn’t doing it’s job.
In case you’re interested, here’s the paper on mast cell disorders: https://www.jacionline.org/article/S0091-6749(17)31025-4/fulltext
Here’s one on the brain and spinal cord: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481533/
The BIGGEST issue with our understanding of the immune system today is that ALL testing is done on mice. The human body on a chip technology along with the digitization of the immune system together will be a monumental step. Thankfully, it’s literally something we’ll have in the near future. Once that’s available, we’ll have human specific data plus an onslaught of constant information, which we need to help folks with all of the immune system disorders. I’m an autoimmune patient and losing my friends and family to this uncertainty has led me into the field to try and help improve our understanding. There’s legit more we don’t know than we do know about the human immune system right now.
While there’s no free floating IgE in your system, to degranulate mast cells need IgE bound to their surface. Thats the activation aspect. Since you need mast cells, it’s not exactly something you can turn off. Glad you know the triggers at least, gives you the opportunity to make moves accordingly!
Here’s a great image of degranulation:
You need two IgE’s to cross-link the same antigen as well, like what is shown above.
Yep! Mast cells are activated when IgE antibodies bind to a mast cell receptor. When IgE then binds to the one object it was designed to find, you get mast cell degranulation. This releases histamines along with a few other chemicals. Degranulation is our immune defense against parasites, so you got a head start for parasite defense for sure! But desensitization can be achieved, which makes IgG antibodies bind to the foreign object before IgE has the chance. I’d think this could be a possible treatment for the syndrome.
Do you also have asthma? The same IgE’s also bind to eosinophil’s. Mast cell degranulation in the lungs leads to acute asthma, whereas when eosinophil’s join the party it causes airway remodeling, aka chronic asthma.
It’s no picnic, parasites are burly! The Th2 adaptive immune response for worms, our only parasite response, is only good with small initial infections. But since the side effects are relatively mild considering all parasites, it’s not a big area of focus.
Fun fact: The same response for parasites causes allergies. You can never be allergic when it’s your first exposure either. But a less hygenic environment as a kid greatly redices the risk of developing allergies.
Of course!
This ones about the evolutionary benefits: The origin of risk aversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273387/
Here’s one on fatal motorcycle accidents: Increased risk of traffic accidents in subjects with latent toxoplasmosis - a retrospective case-control study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117239/
For good measure, here’s one on business owners and the parasite: Risky business - linking Toxoplasma gondii infection and entrepreneurship behaviours across individuals and countries https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083268/
Toxoplasmosis is very intriguing, it has actually evolved alongside cats and humans for ages. While anyone with an immunodeficiency is at higher risk of severe side effects, like with any pathogen, it’s also associated with taking bigger risk. This is why a ton of motorcyclists and casino regulars test positive for the parasite. But when we were hunter gatherers, the infection was associated with bringing home bigger kills, which helped the entire tribe. Due to this, toxoplasmosis infections had sizable benefits and those with the infection often had positions of power in tribes!
While this is all news to me, the biggest difference seems to be that MarkNote allows for rich text notes. I’m curious to know what I’m missing, cause I’d think they could have just added this to KleverNotes.
You’ll want to use the terminal and run “sudo dnf upgrade”. If there’s any issues after that, just run “sudo dnf distro-sync” to ensure everything’s using the final release repo’s. The sync command is strongly recommended but not always necessary.
Fedora’s KDE spin from April forward makes this a nonissue. Plasma 6 makes Wayland and NVIDIA get along like on any other machine. Plus it’s been splendid since Fedora 35 for me.
Edit: I only use Fedora for work, so not too sure what you mean. I make detailed graphical images which are blown up sizably and have had zero issue. Also never have had a problem sharing with Apple or Windows folks (jah help them).
Overtime now, wild game really!
I just screenshot the PDF in fullscreen and then use kolour paint to add in text, it’s worked well for me.
It’ll allow for streaming from a camera directly into OBS. Unless I’m truly horrible with OBS, I currently can only get my screen and audio on a recording. I haven’t found an option to also have my camera feed be recorded along with audio, even with my camera as the mic. Meaning there’s no option to have your face in the bottom corner of a screen recording. So this will allow that to be possible.
Local, that’s what’s so rad about it!
I would dig this, I’d bet it’s in the works. Biggest question is when it’ll be released.
The Linux Experiment covered Asahi (I believe it was Debian) and he said he’ll review the Fedora’s version too. It was a month or two ago and there were some things still in the works. But as a Fedora user and it being Asahi’s flagship which has been fine tuned according to them, I’d bet Nick will post a video soon. If you’re an early adopter, I’d say give Fedora a go now, otherwise just wait for Nick to cover it in his usual detail on his channel. Nick’s the man and will cover it very well. This will probably be the best conformation unless an early adopteradopter or Dev can chime in here.
It’s 100% a feature! Truly a horrendous approach to lock down a device someone purchased to the extent seen on Windows.